Testing Intervention Strategies for the Primary Prevention of Breast Cancer: Phase 2 (Component 2 Full Award)

This initiative aims to fill gaps in evidence about the effectiveness of community-level intervention strategies for a priority set of breast cancer risk factors detailed in Paths to Prevention, the California Breast Cancer Primary Prevention Plan.

In 2022, CBCRP awarded two Component 2 Pilot Awards to test new and integrated intervention strategies that specifically address chemical exposures and other factors, to reduce occupational and/or environmental exposures as well as align with broader community concerns.

CBCRP is currently sponsoring a Request for Proposals (RFP) for a Component 2 Full Award. This Call is open to any California applicants whether they received a Component 2 Pilot or not. Any individual or organization in California may submit an application. The research must be conducted primarily in California.

Download the RFP below:

Full Request for Proposals (RFP)

Application materials are available through CBCRP's SmartSimple application and grant management system.

Applications must be submitted by 12:00 Noon PT on Thursday, August 8, 2024. 

Applicant WEBINAR

CBCRP held an informational webinar for prospective applicants on May 16, 2024. Slides and a recording of the webinar are available:

• Slides (pdf) - 800KB
• Recording (mp4) - 55MB

For questions or more information, contact CBCRP Program Officer Sharima Rasanayagam, Ph.D. at sharima.rasanayagam@ucop.edu

Specific Aims and Activities

As stated in the Phase 1 RFP, available at Testing Primary Prevention 1 RFP, Component 2 of this initiative has two phases. Phase 1 was offered as a Pilot Award and Phase 2 is now being offered as a Full Award.

For this Component 2 Full Award, CBCRP is looking for proposals to test a new, integrated intervention strategy that addresses chemical exposures in relation to broader social contextual factors, to reduce occupational and/or environmental exposures as well as improve and promote overall health and wellness. The intervention to be tested, which could be a modification to an existing intervention strategy not yet implemented in California, should be conducted within a cohort of women with shared workplace and/or place-based exposure to harmful chemicals or ionizing radiation. The integrated intervention strategy should address intervention goals related to occupational and/or place-based exposures, within the context of the first two risk factors in Paths to Prevention: race, power, and inequities; and the social and built environment. The outcomes of interest are reduction in cohort-wide harmful exposures for breast cancer and improvement in cohort-wide measures of health (improvements in health behaviors or a reduction in the prevalence or severity of a chronic health condition), within a five-year project period.

For Component 2, an integrated intervention, the strategies to be tested should be designed to reduce harmful exposures and promote health in a community by mitigating a combination of chemical and other risk factors from Paths to Prevention. The priority risk factors, and the focus of associated intervention goals of special interest, are:

• Race, power, and inequities
  • build power and capacity to drive societal change
  • expand culturally appropriate education and awareness
  • endorse and support movements that address discrimination, marginalization, and oppression
• Social and built environment
  • develop safe walk, bicycle and public friendly cities to enhance physical activity and reduce transit-related pollution
  • ensure low-income housing is free from pollutants
  • accessible and safe indoor and outdoor recreation spaces
• Occupation
  • make workplaces safer
    • eliminate hazardous chemicals and practices from workplaces, with an emphasis on breast cancer risks
    • focus on actions specific workforces (such as salon workers and janitorial workers) can take to protect themselves immediately
  • Place-based chemicals
    • reduce exposures to harmful exposures and pesticides in public places

Project requirements

The research must be conducted as community-partnered participatory research (CPPR). The research teams must include representatives described below working collaboratively throughout the project:

• At least one California-based community organization (formal or informal)
• Community members, including patients, clients or interested people
• At least one experienced academic researcher working in California in an appropriate discipline and setting

Each team must have one person designated as the “Community co-principal investigator (co-PI)” and one as the “Academic co-PI.”

Each application must include a dissemination plan that includes methods to ensure the implementation of findings.

Project duration and budget cap

CBCRP intends to fund one Component 2 Full Award.

• Maximum direct cost budget: $1,825,000
• Project duration: 5 years