Chemical Safety Testing to Reduce Breast Cancer Risk
As part of our Prevention Initiatives, CBCRP intends to fund two types of projects related to chemical safety testing and breast cancer risk.
Lack of data on toxicity makes the task of evaluating the impacts of exposure to many chemicals on breast cancer risk unachievable. There is a need to reform chemicals policies in ways that would mandate such testing and take action on the basis of what is known. But it is also critical to create a toxicity testing strategy for breast cancer that would identify biological mechanisms that play a role in breast cancer and develop new tests to screen for activity in these mechanisms.
Download the full RFP or review the two types of projects below.
Full Request for Proposal (pdf)
To learn more about the application process, see the California Breast Cancer Prevention Initiatives Submission Instructions (pdf). Application materials are available on proposalCENTRAL.
Note: At this time, the application period for these awards is closed. The RFP is available for information purposes only.
1. DEVELOP NEW TESTING METHODS FOR IDENTIFYING AND TESTING CHEMICALS FOR THEIR POTENTIAL TO CONTRIBUTE TO BREAST CANCER
Up to four topics of this type will be funded. The following are areas of interest:
- Advance the understanding of chemically-induced biological pathways to breast cancer as a basis for designing chemical safety tests,
- Develop or improve tests targeting biological gaps in current screening/testing strategies in order to improve tools for identifying potential breast carcinogens,
- Test additional chemicals in existing or new tests to identify toxicants relevant to mammary carcinogenesis and development, and/or
- Evaluate the predictive validity of suites of tests using existing or newly generated data.
Project duration and budget caps for project type 1
- Maximum duration: 3 years
- Budget cap for total project direct costs: $900,000 ($300,000/year)
2. IDENTIFY SYNERGIES BETWEEN and aid in the translation of research outcomes to policy
CBCRP began funding an earlier round of improved chemical testing methods in 2011. The results of these efforts are beginning to materialize, though further investigation is needed to advance the field. Additionally, the lessons learned through the first and second phase of this research need to be interpreted for synergies and translated so the findings can be relevant to policy interventions to prevent breast cancer.
One project will be funded to identify synergies between CBCRP-funded projects (previously or concurrently funded chemical testing projects) and translate the outcomes for policy development relevant to breast cancer.
Project duration and budget caps for project type 2
Preferably awarded in conjunction with one project type 1 award.
- Maximum duration: 3 years
- Budget cap for total project direct costs: $150,000